Oct 25, 2020

Drug Resistance In Cancer Mechanisms And Models

drug resistance in cancer mechanisms and models

The major mechanisms of resistance include tumor evolution and tumor heterogeneity, acquired secondary genetic alterations, signaling pathway feedback loops and bypass mechanisms, and the tumor microenvironment. 4,5 Drug resistance in each case could involve one or more of these major mechanisms, depending on the class of drugs and therapeutic treatment strategies being employed 5,6.

Drug Resistance in Cancer: Mechanisms and Models: Amazon ...

Drug Resistance in Cancer: Mechanisms and Models | Goldie, James H., Coldman, Andrew J. | ISBN: 9780521482738 | Kostenloser Versand für alle Bücher mit Versand und ...

A view on drug resistance in cancer | Nature

Drug resistance in cancer, whereby a portion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly explained in this volume. A deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumor growth, including spontaneous mutation and selection processes. The authors seek to explain ...

lncRNA and Mechanisms of Drug Resistance in Cancers of the ...

Drug resistance is a frequent clinical problem for cancer patients ().Many mechanisms of drug resistance have been found (2, 3).For example, drugs can be prevented from entering the cells; drugs can be pumped out of cells; they can be enzymatically inactivated; drug activity can be prevented by mutation or altered expression of the target; and defects in apoptosis, senescence, and repair ...

Challenges and Opportunities in Cancer Drug Resistance ...

Dexamethasone induced cisplatin resistance via KLF-5 to promote cell proliferation can occur via many mechanisms including through regulation of cyclin D, fibroblast growth factor binding protein 1, microsomal prostaglandin E2 synthase [ 43 - 45]. In the treatment of cervical cancer, GCs may also play a role in response to therapy.

Circumventing Cancer Drug Resistance in the Era of ...

Two known models, the cancer stem cell (CSC) model, and the environment-mediated drug resistance (EMDR) model, which are not mutually exclusive, could explain the origin of resistant cells. In the CSC model, rare populations of cancer stem cells possess tumor-initiating properties (Teicher, 2006; Nguyen et al., 2012).

Mechanisms of doxorubicin-induced drug resistance and drug ...

Cancer drug development can feel like a depressing game of whack-a-mole. No sooner does a new drug move into the clinic, than do researchers start to see the rise of resistance mechanisms that can ...

Cancer Drug Resistance

Drug resistance develops in nearly all patients with colon cancer, leading to a decrease in the therapeutic efficacies of anticancer agents. This review provides an up-to-date summary on over-expression of ATP-binding cassette (ABC) transporters and evasion of apoptosis, two representatives of transport-based and non-transport-based mechanisms of drug resistance, as well as their therapeutic ...

Drug Resistance Mechanisms in Colorectal Cancer Dissected ...

Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type-Specific Dynamic Logic Models. Eduati F(1), Doldàn-Martelli V(1)(2), Klinger B(3)(4), Cokelaer T(1), Sieber A(3)(4), Kogera F(5), Dorel M(3)(4)(6), Garnett MJ(5), Blüthgen N(7)(4)(6), Saez-Rodriguez J(8)(9). Author information: (1)European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI ...

Cancer Drug Resistance

However, it is still unclear whether this mechanism explains cancer cell drug resistance in patients or whether the active survival mechanisms that have been discovered in experimental models ...

Understanding Cancer Drug Resistance by Developing and ...

Cancer Research UK has recently sponsored a meeting, organized by the UK Medical Research Council, on cancer drug resistance. Several of the molecular mechanisms responsible for this clinical outcome, such as DNA interstrand crosslink repair, apoptosis evasion, cytochrome P450 and P-glycoprotein, were discussed. There was a special focus on leukaemia, breast and ovarian cancer, and the ...

Drug resistance in cancer : mechanisms and models (Book ...

Cancer Drug Resistance aims to provide a forum for all types of drug resistance, in order to identify or elucidate the mechanism of resistance and importantly, how to bypass the resistance. Novel targeted drugs, usually consisting of a multitarget tyrosine kinase inhibitor (TKI) or a serine-threonine protein kinase inhibitor, were originally developed with the assumption, that being targeted ...

Targeting MAPK Signaling in Cancer: Mechanisms of Drug ...

Drug Resistance in Cancer: Mechanisms and Models: Goldie, James H., Coldman, Andrew J.: Amazon.nl

Cancer Drug Resistance

In this study, to examine therapy-induced drug resistance and cancer metastasis, we designed a novel stochastic model that connects the biological mechanisms underlying cancer drug resistance to ...

Using physics, math and models to fight cancer drug ...

At the level of the tumour, various resistance mechanisms can operate, such as increased drug efflux, mutations of the drug target, DNA damage repair, activation of alternative signalling pathways...

Multiple Drug Resistance Mechanisms in Cancer

the experimental models can be easily generated by in vitro selection with cytotoxic compounds, cellular mechanisms of drug resistance in cancer have been intensively studied so far[12]. Given the accumulating literature regarding this field, the present review will focus on cellular mechanisms of drug resistance in colon cancer and its reversal strategies, with an emphasis on the over ...

Biological Mechanisms and the Advancing Approaches to ...

1. Introduction. Cancer treatment is constantly evolving, and life expectancy has increased for certain cancer types in the last 50 years. Nonetheless, cancer is still the third leading cause of death from noncommunicable diseases worldwide [].The main reason for this high mortality is the lack of effective treatments to overcome the natural acquisition of resistance.

Multi-Drug Resistance in Cancer | SpringerLink

Mechanism-based model for tumor drug resistance. Kuczek T(1), Chan TC. Author information: (1)Department of Statistics, Purdue University, West Lafayette, IN 47907. The development of tumor resistance to cytotoxic agents has important implications in the treatment of cancer. If supported by experimental data, mathematical models of resistance can provide useful information on the underlying ...

Mechanisms of Resistance to PARP ... - Cancer Discovery

Introduction. Multi-drug resistance (MDR) is defined as the resistance of cancer cells to one chemotherapeutic drug accompanied by resistance to other chemotherapeutic drugs that may have different structures and mechanisms of action .Specifically, once cancer cells gain resistance to drugs that are structurally and functionally unassociated, even to the drugs that have not been exposed ...

Molecular Mechanisms of Drug Resistance And Strategies of ...

(1) Mechanism-based mathematical models can quantitatively describe the cancer drug response based on known mechanisms but fall short in discovering novel molecules, biomarkers or targets for cancer drug resistance. (2) The most mathematical models used for cancer drug resistance, for instance, kinetic network model, are based on the experimental data generated from cell lines or animal models ...

Mechanisms of Resistance to Antibody–Drug Conjugates ...

Gomez Tejeda Zañudo J, Mao P, Montero J, et al. Network modeling of drug resistance mechanisms and drug combinations in breast cancer. Presented at: American Association for Cancer Research (AACR ...

Dissecting the Mechanisms of Drug Resistance in BRCA1/2 ...

Although in vitro models have been a cornerstone of anti-cancer drug development, their direct applicability to clinical cancer research has been uncertain. Using a state-of-the-art Taqman-based quantitative RT-PCR assay, we investigated the multidrug resistance (MDR) transcriptome of six cancer types, in established cancer cell lines (grown in ...

Cancer drug resistance: an evolving paradigm

Please use one of the following formats to cite this article in your essay, paper or report: APA. Henderson, Emily. (2020, June 23). Improving cancer therapies by exploiting drug resistance in cancer.

[PDF] Hybrid Modeling of Cancer Drug Resistance Mechanisms ...

Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA Poly (ADP) ribose polymerase inhibitors (PARPi) have shown promising activity against recurrent ovarian cancers, particularly in women with germ line mutations of BRCA1/2. The efficacy of PARP inhibitors can, however, be decreased by acquired drug resistance. Autophagy or “self-eating” is one mechanism implicated in ...

Mouse xenograft models for elucidating drug resistance ...

Resistance mechanisms to drug therapy in breast cancer and other solid tumors: An opinion [version 1; peer review: 2 approved, 1 approved with reservations] Fedor V. Moiseenko , Nikita Volkov, Alexey Bogdanov , Michael Dubina , Vladimir Moiseyenko2 St Petersburg Academic University, St. Petersburg, 194021, Russian Federation St. Petersburg Clinical Research and Practical Center for Specialized ...


Drug Resistance In Cancer Mechanisms And Models



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Drug Resistance In Cancer Mechanisms And Models